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Daniel Pierson

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Open access Aug 2026

Kinetics, thermodynamics, and mechanisms of PMO interactions from computational molecular modeling

Phosphorodiamidate morpholino oligonucleotides (PMOs) are a class of antisense oligonucleotides. While PMOs have enabled several nucleic acid therapeutics, their structural and energetic solution properties remain poorly understood. Using solution viscosity measurements combined with computational molecular modeling, w...

Ying Chou, Igor Novikov, Daniel Pierson et al. · 0 citations

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