Thermoneutrality accelerates a distinctive metabolic dysfunction-associated steatohepatitis phenotype in a diet-induced male mouse model with similarities to human disease.
BACKGROUND & AIMS Metabolic dysfunction-associated steatohepatitis (MASH) is a prevalent chronic liver disease characterized by steatosis, inflammation, and hepatocyte damage, with or without fibrosis. Robust preclinical models that represent the clinical features of MASH are critical for drug development. We aimed to...