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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Daniel Hilger

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3 papers indexed here

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Open access Oct 2026

Ligand-dependent G protein dynamics underlying opioid efficacy

Activation of heterotrimeric G proteins by G-protein-coupled receptors (GPCRs) requires large-scale opening of the Gα α-helical domain (AHD) to expose the nucleotide-binding site and facilitate GDP–GTP exchange. Although orthosteric ligands are known to modulate GPCR conformation, how these effects propagate to the bou...

Jonathan C. Deutsch, Daniel Hilger, John Janetzko et al. · 1 citation
Open access Aug 2026

Discovery of a Cell-Permeable Gi-Signaling Inhibitor

N-hydroxyapiosporamide (NHAP) is established as a first-in-class Gi-selective inhibitor, providing a cell-permeable chemical scaffold for the optimization of next-generation agents to control Gi-signaling in cell-based systems and, ultimately, to target Gαi1-driven pathologies.

A. Naimi, Tim Berger, Philipp Dahlhaus et al. · 0 citations

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