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Author

Daniel Coles

2 papers indexed here

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Open access Sep 2026

Developing Interim Outcome Measures for Multi-Arm Multistage Clinical Trials in Multiple Sclerosis

Background and Objectives Multi-arm multistage (MAMS) clinical trials use interim outcome stage analyses to test multiple candidate treatments, determining which should proceed to the next trial stage. The reduced time, cost, and participant numbers, compared with current separated phases 2 and 3 clinical trials, could...

Sean Apap Mangion, Charles Wade, Daniel Coles et al. · 0 citations
Review Open access Oct 2026

The efficacy of surgical interventions for trigeminal neuralgia in multiple sclerosis: A systematic review

Trigeminal neuralgia affects approximately 3% of patients with multiple sclerosis – a far higher prevalence than in the general population. The associated pain often proves refractory to medication, prompting consideration of neurosurgical intervention. The variable efficacy, tolerability, and durability of available p...

Anish Kalyana, Daniel Coles, S. Khalil et al. · 0 citations

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