What deep learning can and cannot (yet) do for enzyme design.
Deep learning has substantially advanced structure-based enzyme design, yet reliably creating highly efficient enzymes remains out of reach. One emerging enzyme design strategy combines diffusion-based scaffold generation around active-site models with sequence design. Such structure-based approaches have expanded the...
Judith A. Ahr, Moor de Waal, Tudor-Stefan Cotet et al.
· Current Opinion in Chemical... · 1 citation