Emergence of glycolysis-lactate-Lactylation Axis in breast cancer: Mechanisms, tumour progression, and therapeutic implications.
Breast cancer is a uniquely metabolically reprogrammed cancer, with increased aerobic glycolysis, excess lactate production, and the development of an excess of lysine lactylation. This glycolysis-lactate-lactylation signal has become a key player in the control of tumour growth and resistance to treatment. This review...