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Author

Dania Abdellatif

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Jul 2026

Disrupted WWOX-MYC interplay impairs neurogenesis in human brain organoids.

A model in which WWOX mutations impair neurogenesis via RG through cell-type specific dysregulation of the MYC and Wnt signaling pathways is proposed, highlighting potential therapeutic strategies for WWOX-related disorders and open avenues for interventions targeting these key molecular pathways.

Daniel J. Steinberg, A. Zonca, Dania Abdellatif et al. · 0 citations
Open access Aug 2026

Modeling and targeting haploinsufficiency in SHINE syndrome

These findings establish DLG4 haploinsufficiency as a shared consequence of pathogenic DLG4 variants, while revealing additional variant-associated effects on neuronal structure and activity, rescued by AAV9-mediated neuronal restoration.

Dania Abdellatif, Mustafa Obeid, Rami I. Aqeilan · 1 citation

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