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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Dana R. Crawford

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Review Open access Aug 2026

The estrogen-integrin αvβ3 crosstalk in breast cancer: Modulating PD-L1 and immune evasion.

The mechanisms governing PD-L1 expression in breast cancer are highly complex and context-dependent. This article proposes a novel "dual-track" regulatory model to resolve the conflicting roles of estrogen in tumor immunity. Genomic signaling through ER-α suppresses PD-L1 transcription, explaining lower PD-L1 levels in...

Dana R. Crawford, Yung-Ning Yang, Feng-Cheng Liu et al. · 0 citations

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