Open access
Oct 2026
Tianwang Buxin Dan regulated PI3K/Akt/mTOR signaling pathway to improve constipation and emotional disorders in rats
Functional constipation (FC) is frequently comorbid with anxiety and depression, yet pharmacological strategies targeting both gastrointestinal and emotional symptoms remain limited. This study investigated the therapeutic effects and molecular mechanisms of Tianwang Buxin Dan (TWBXD), a classical Chinese herbal...
He-Wen Wang, Xin-Ran Li, Zhao-Yu Chen et al.
· Frontiers in Medicine · 0 citations