Author

Dan-Yang Zhao

2 papers indexed here

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Open access Aug 2026

Chrysosplenetin-induced TMED3 aggregation triggers unfolded protein response in pancreatic cancer

Pancreatic cancer (PC) continues to demand urgent therapeutic innovation given its limited treatment options. Here, through phenotypic screening of a natural product library followed by systematic validation, we identified chrysosplenetin (CHR) as a bioactive compound with anti-PC activity. Transcriptomic profiling and...

Zhe Zhang, Ning-Na Weng, Xuan-Hao Gu et al. · EMBO Molecular Medicine · 0 citations

Open access Sep 2026

MG53 suppresses IRF7 to reprogram macrophages and promote antitumor immunity in pancreatic ductal adenocarcinoma.

In pancreatic ductal adenocarcinoma (PDAC), the desmoplastic stroma and immunosuppressive tumor microenvironment (TME) present barriers to immunotherapy. Here, we show that MG53 (TRIM72) is a critical regulator of macrophage fate and anti-tumor immunity; its myeloid-specific depletion accelerates PDAC progression by lo...

Yu-Meng Pei, Meng Fang, Fan Zhang et al. · Cell Reports · 0 citations