Dan-Yang He

In vivo multimodal lineage tracing of mammalian development by DeepTrack barcoding

DeepTrack is presented, a lineage tracing mouse model that integrates in situ cellular barcoding with high-throughput, single-cell multi-omics to simultaneously profile clonal fates, transcriptomic states, and chromatin accessibility and provides a versatile framework for decoding multimodal regulation of cell fate acr...