Dan Teng

Targeting the FOXP3—T-bet interaction to restore Treg stability in IFN-γ—driven autoimmunity 2254306

Regulatory T cells (Tregs) maintain immune homeostasis through FOXP3-centered transcriptional complexes that tightly control lineage stability and suppressive function. However, how specific FOXP3 mutations disturb this complex and drive pathogenic Treg reprogramming in IPEX syndrome remains unclear. We identifie...

Targeting the FOXP3–T-bet interaction to restore Treg stability in IFN-γ–driven autoimmunity

MG2Act: A Mechanism-Inspired Sequential Attention Framework for Molecular Glue Degradation Prediction

This work presents MG2Act, a structure-independent framework that translates two-step logic into sequential cross-attention, using CRBN-mediated degradation as the most data-rich representative system.

Deep residual learning for molecular force fields

In tests covering drug-like molecules, molecular dimers, torsional energy profiles, energy-minimum structures, and biomolecular simulations, Residual Learning Force Field gives accurate and stable predictions across diverse systems.