Dan Mu

The ATG4 family: Molecular gatekeepers of autophagic flux and emerging targets for disease intervention.

Autophagy represents an evolutionarily conserved intracellular degradation pathway. Aberrant activation or impaired autophagic flux contributes substantially to the pathogenesis and progression of numerous human diseases, such as tumors and neurological disorders. As the only cysteine proteases within the core autophag...