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Dan Liu

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Aug 2026

Mechanistic Characterization of GedF Reveals a Ser-Tyr Catalytic Core with a Flexible Basic Residue in a Filamentous Fungal Anthraquinone SDR.

The cleavage of the C10-C4a bond in anthraquinones is a key step in generating ring-opened quinone derivatives in filamentous fungi. GedF, a short-chain dehydrogenase/reductase (SDR) from Aspergillus terreus, together with the dioxygenase GedK, mediates this transformation, yet the enzymatic mechanism of GedF remains u...

Ning Xu, Yongsong Wu, Dan Liu et al. · 0 citations

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