Open access
Sep 2026
High-throughput functional characterization of enhancers in totipotent-like cells
Zygotic genome activation (ZGA) marks the initial transcription event in embryogenesis, yet the cis-regulatory mechanism remains unclear. Here, utilizing massively parallel reporter assays, we functionally dissect enhancers across mouse genome in DUX-induced 2C-like cells (2CLCs). Through integrated analysis with epige...
Ling-Yu Yang, Tian-Ran Peng, Ya-Ting Zhu et al.
· Nature Communications · 0 citations