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Open access Aug 2026

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

ABSTRACT Despite substantial progress in KRAS‐targeted therapies, specific inhibitors of the KRAS G13D mutant remain unavailable. In a retrospective analysis, we found a notable downregulation of glutathione peroxidase 2 (GPX2) in KRAS G13D‐ mutant colorectal cancer (CRC), which correlated with poor outcomes. We hypoth...

Xiaoting Liu, Chong Wu, Shiyao Song et al. · 0 citations
Aug 2026

Janus Nanozyme With Programmable Catalytic Switching for Adaptive Therapy of Diabetic Wounds.

Diabetic wound healing requires dynamic bidirectional regulation of reactive oxygen species (ROS). Herein, guided by density functional theory (DFT) calculations, we propose a programmable strategy to engineer catalytic pathways via an intimate heterointerface in Janus-structured Cu-Ag nanoparticles (CuAg-J). Theoretic...

Xuelian Wei, Zheng-Xiang Gu, Yan-Ge Luan et al. · 0 citations

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