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Author

Dan I. Andersson

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Open access Oct 2026

Unstable Heteroresistance as a Stepping Stone to Stable Resistance via Compensatory Mutations

Antibiotic heteroresistance, a trait in which a drug-susceptible population harbors a rare resistant subpopulation, has been presented as an unstable intermediate state on the way to classic stable antibiotic resistance. However, the timescales and pathways under which this could occur has not been examined. Extending...

B. Berryhill, Dan I. Andersson · 0 citations
Open access Aug 2026

Novel phage-plasmid mediated mechanism of antibiotic heteroresistance in Escherichia coli

A novel mechanism of HR by gene copy number increase is identified and further elucidates the role of phage-plasmids in antibiotic resistance development and spread and shows that a piperacillin-tazobactam-selected increase in phage-plasmid copy number did not increase the rate of horizontal transfer of the phage-plasm...

Elin Svedholm, E. Joffré, Caroline Sentell et al. · 0 citations
Aug 2026

Distinct plasmid- and host-encoded mechanisms drive small plasmid copy number-mediated heteroresistance in Escherichia coli

This study investigates the contribution of small plasmids to heteroresistance using a clinical bloodstream Escherichia coli isolate carrying a 12 kb ColE1-type plasmid, and shows that this plasmid drives transient β-lactam heteroresistance through massive increases in plasmid copy number.

Angelika Ntokaki, E. Joffré, Bart Melgers et al. · 0 citations

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