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Bioassays indicated that most compounds displayed potent insecticidal activity against Plutella xylostella and Spodoptera litura, and FSC36 exhibited the highest activity, with LC50 values, overcoming the “high efficacy–high toxicity” challenge.
Peanut stem rot, caused by the soil-borne pathogen Sclerotium rolfsii, poses a significant threat to global peanut production and results in substantial yield losses. A series of thiocarbamate derivatives were synthesized and evaluated against ten phytopathogenic fungi. Over 50% showed broad-spectrum fungicidal activ...
A1 and A2 are identified as promising, bee-safe leads for next-generation SDHI fungicides based on a 3,5-dichloro-2,6-difluoropyridin-4-amine scaffold and disrupt mycelial morphology and inhibit SDH, supported by molecular docking and enzyme activity assays.
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