Author

Dan-Dan Huang

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Open access Oct 2026

A genomic foundation model for interpreting human genetic diversity

Interpreting human genomes requires models that recognize shared biological functions while accounting for variation underlying traits, disease susceptibility and adaptation. Here we present hEVO, a genomic foundation model trained on 4.784 billion distinct haplotype sequences reconstructed from whole genome sequencing...

Qin-Yi Xu, Zhi-Kun Wu, Mei-Jing Dong et al. · bioRxiv · 0 citations

Open access Sep 2026

Single-cell multiomic QTL mapping reveals state-dependent genetic regulation and associated gene during cellular senescence

How cellular senescence reshapes inherited regulatory effects across chromatin and transcription, and eventually contribute to non-coding risk loci of complex diseases, remains elusive. We generated single-cell multiome ATAC-RNA profiles from proliferating and replicatively senescent primary HUVECs derived from 100 gen...

Xian-Fu Yi, Xue-Qi Wang, Kun-Lun Liu et al. · bioRxiv · 0 citations

Open access Sep 2026

HOTAIR Promotes Prostate Cancer Progression by facilitating CDK9-Pol II Association and Transcriptional Elongation

Previous research has predominantly focused on the regulatory role of lncRNA HOTAIR in gene silencing by interacting with the Polycomb repressive complex 2 (PRC2), but its direct role as a transcriptional activator remains less well characterized. Here, our study reveals a novel regulatory mechanism of HOTAIR, which fa...

Yu-Yang Qian, Bo Wang, Guang-Song Su et al. · International Journal on Bio... · 0 citations