Sep 2026
Mechanism of cancer-associated fibroblasts-derived exosomes-shuttled snail regulating the SOCS6/HIF-1α axis to promote pancreatic cancer stemness and gemcitabine resistance.
OBJECTIVE Cancer-associated fibroblasts (CAFs) contribute to pancreatic cancer (PC) progression and therapeutic resistance. This study investigated whether CAF-derived exosomes (CAF-exo)-promote PC cell stemness and gemcitabine (GEM) resistance by delivering Snail and regulating the suppressor of cytokine signaling 6/h...
Zhen Luo, Yuqin Hu, Jian Li et al.
· Cellular Signalling · 0 citations