Author

Da-Qiu Chen

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Open access Oct 2026

Real-world safety of vericiguat as a fifth-line agent in heart failure: a pharmacovigilance study of quintuple therapy

Background Vericiguat, a novel soluble guanylate cyclase (sGC) stimulator, is indicated for high-risk worsening heart failure (HF). However, its real-world reporting profile when added to contemporary quadruple guideline-directed medical therapy (GDMT)—effectively creating a “quintuple” regimen—remains largely unexplor...

Da-Qiu Chen, Y. Wu, Zi-Xun Wang et al. · Frontiers in Cardiovascular... · 0 citations

Review Open access Sep 2026

Divergent mortality associations of TyG-BMI in middle-aged and older adults: Parallel analyses of Chinese and US populations.

BACKGROUND To compare the association between TyG-BMI and all-cause mortality in Chinese and US middle-aged and older adults using parallel, dataset-specific analytical approaches. METHODS A comparative analysis was conducted using data from the China Health and Retirement Longitudinal Study (CHARLS) and the US Natio...

Da-Qiu Chen, Zi-Xun Wang, Zhan-Xiong Xie et al. · Experimental Gerontology · 0 citations

Review Open access Aug 2026

Gut-derived metabolites and mitochondrial homeostasis in heart failure: mechanistic links and translational perspectives

Current evidence linking gut-derived metabolites to myocardial mitochondrial homeostasis in heart failure is summarized, with emphasis on energy metabolic remodeling, oxidative stress, inflammation, mitochondrial quality control, cell death, and fibrotic remodeling.

Da-Qiu Chen, Ming-Xuan Su, Zhan-Xiong Xie et al. · Frontiers in Cardiovascular... · 0 citations