Review
Open access
Oct 2026
Malignant remodeling of the bone marrow microenvironment in acute myeloid leukemia: mechanisms and therapeutic implications
Acute myeloid leukemia (AML) is an aggressive clonal myeloid malignancy characterized by the expansion of differentiation-arrested blasts. Treatment resistance, measurable residual disease, and relapse remain major causes of treatment failure. Experimental and clinical evidence indicates that the bone marrow microenvir...
Wen-Hao Xu, Qing-Lian Han, Chang-Rong Sun et al.
· Frontiers in Oncology · 0 citations