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Host-Directed Discovery of Dynamic-Covalent Guests From Dynamic Combinatorial Libraries.
Dynamic covalent chemistry and host-guest recognition are complementary tools for constructing adaptive molecular systems and functional materials, yet their integration has been hindered by the lack of general strategies for efficiently discovering host-compatible dynamic-covalent guests. Here we report a host-directe...
Dynamic Fluorescence Visualization of Nonequilibrium Supramolecular Assembly Regulated by a Proton Reservoir.
Living systems sustain nonequilibrium supramolecular assemblies through continuous energy input and concomitant dissipation, with adenosine triphosphate (ATP) serving as a universal chemical fuel that regulates dynamic processes by coupling hydrolysis to downstream chemical or conformational changes. Biomimetic recreat...