Author

Da-Feng Liu

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Open access Aug 2026

Functional and mechanistic characterization of the phosphatidyl-myo-inositol mannosyltransferase PimA from Mycobacterium tuberculosis: implications for anti-tuberculosis drug development

Human-adapted Mycobacterium tuberculosis (Mtb) also infects animals and transmits zoonotically, threatening public health. The cell wall glycolipids lipoarabinomannan and lipomannan are essential virulence factors of Mtb. Phosphatidyl-myo-inositol mannosyltransferase PimA catalyzes a key step in their biosynthesis and...

Da-Feng Liu, Hua-Shui Deng, Xinbao Liu et al. · Frontiers in Cellular and In... · 1 citation

Open access Sep 2026

The Flexible Peripheral Segments Modulate the Catalytic Activity of the FAD-Containing Monooxygenase EthA from Mycobacterium tuberculosis

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health concern, particularly due to the emergence of drug-resistant strains. FAD-containing monooxygenase EthA activates the antitubercular prodrug ethionamide (ETH) in Mtb. However, the structural and functional mechanisms of Mtb Eth...

Da-Feng Liu, Xie-Ping Sun, Feng Yu et al. · Biomolecules · 0 citations

Open access Sep 2026

The Dephospho-CoA Kinase of Mycobacterium tuberculosis: Molecular Mechanism and Function.

The found that the S15A, R145A or N175A mutants showed markedly reduced activity, whereas the K14A mutation completely abolished activity, and deletion of residues 27-101 (Δ27-101) led to a significant loss of function.

Da-Feng Liu, Hua-Shui Deng, Hong-Jun Song · ACS Omega · 0 citations