The increase in PRS was associated with elevated risks of both metastatic CRC at diagnosis and CRC-specific mortality, indicating delayed diagnosis in high-PRS individuals and highlighting the potential benefit of earlier screening.
Wen Sun, Di Liu, Dong-Xue Wang et al.· International Journal of Can...· 0 citations
Pathway‐specific polygenic risk scores (psPRS) provide insights into the heterogeneity of type 2 diabetes. We aim to study whether psPRS for beta cell dysfunction, obesity and metabolic syndrome associate with risk of hyperglycaemic progression in Southeast Asian patients with type 2 diabetes.
Sylvia Liu, Hui-Li Zheng, Jia Le Ivan Tan et al.· Diabetes, obesity and metabo...· 0 citations
Depressive symptoms show a gradual increase before CVD diagnosis, elevate further around the time of diagnosis, and continue to worsen thereafter, calling for the integration of mental health screening and management into CVD care at all stages, from primary prevention to long-term disease management.
Jiao Wang, Zhi-Yuan Wu, Xin-Ye Zou et al.· European Journal of Preventi...· 0 citations
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