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Open access Oct 2026

Integrating Polygenic Risk Score, Sex, and Family History to Personalize the Initial Screening Age for Colorectal Cancer.

The increase in PRS was associated with elevated risks of both metastatic CRC at diagnosis and CRC-specific mortality, indicating delayed diagnosis in high-PRS individuals and highlighting the potential benefit of earlier screening.

Wen Sun, Di Liu, Dong-Xue Wang et al. · 0 citations
Open access Sep 2026

Pathway‐Specific Polygenic Risk Score and Risk of Hyperglycaemic Progression in Patients With Type 2 Diabetes

Pathway‐specific polygenic risk scores (psPRS) provide insights into the heterogeneity of type 2 diabetes. We aim to study whether psPRS for beta cell dysfunction, obesity and metabolic syndrome associate with risk of hyperglycaemic progression in Southeast Asian patients with type 2 diabetes.

Sylvia Liu, Hui-Li Zheng, Jia Le Ivan Tan et al. · 0 citations
Open access Sep 2026

Depressive Symptoms Trajectories Across the Transition to Cardiovascular Disease in Middle-Aged and Older Adults: A Multicohort Study.

Depressive symptoms show a gradual increase before CVD diagnosis, elevate further around the time of diagnosis, and continue to worsen thereafter, calling for the integration of mental health screening and management into CVD care at all stages, from primary prevention to long-term disease management.

Jiao Wang, Zhi-Yuan Wu, Xin-Ye Zou et al. · 0 citations

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