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D. York

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Open access Oct 2026

ΔNAzyme: A Foundational QM/MM Δ-Machine Learning Potential for Nucleic Acid Enzyme Catalysis.

Nucleic acid enzymes (NAzymes), including ribozymes, DNAzymes, and XNAzymes, are programmable biocatalysts that catalyze diverse chemical reactions and provide unique platforms for investigating catalysis and engineering molecular function. Their central roles in biology and evolution, together with emerging applicatio...

Erika McCarthy, Timothy J. Giese, Solen Ekesan et al. · 0 citations
Open access Aug 2026

Mechanical Caging of Nucleic Acids Enabled by Light-Activated Synthetic Molecular Motors

Control over nucleic acid activity is central to biotechnology and therapeutic development. Most existing strategies rely on installing protecting groups that mask nucleobases or backbone functionalities (i.e., chemical caging), where modulation of activity arises from alteration of the biomolecule’s chemical identity....

Yuchen Ma, Erika McCarthy, N. Murthy et al. · 0 citations

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