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D. Wightman

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Open access Oct 2026

Alzheimer's disease genetics converges on microglial and neuronal dysregulation.

Alzheimer's disease (AD) is the most common cause of dementia, with global case numbers projected to reach 153 million in 20501. AD is highly heritable, with twin-based heritability estimates of 60-80%2. Although 1,200 causal loci are predicted to exist for AD3, approximately 80 loci have been associated with AD in two...

E. Uffelmann, D. Wightman, S. Bahrami et al. · 0 citations

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