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Open access Sep 2026

Development, Validation, and Clinical Application of a Simultaneous Quantification Method of Seventeen Antituberculosis Drugs in Plasma, Serum, or Saliva Using LC-MS/MS.

BACKGROUND Tuberculosis (TB) remains a global health issue. Treatment involves multiple anti-TB drugs, and pharmacokinetic variability may lead to toxicity or ineffective treatment. Therapeutic drug monitoring may help address these challenges. This study aimed to develop a rapid method to analyze anti-TB drugs in plas...

M. Bolhuis, E. M. Jongedijk, O. Akkerman et al. · 0 citations
Open access Sep 2026

Target Attainment and Clinical and Biochemical Parameters Associated with the Pharmacokinetics of 12 Tyrosine Kinase Inhibitors.

BACKGROUND AND OBJECTIVE Tyrosine kinase inhibitors (TKIs) are targeted cancer therapies. However, TKIs are still limited due to their high inter-individual variability. This study evaluated target attainment using therapeutic drug monitoring (TDM) data from 12 TKIs, and investigated biochemical and patient-related cha...

Zaid N. Al Shirity, P. Mian, A. Dontje et al. · 0 citations
Open access Aug 2026

Pharmacogenetic Profiling of Allogeneic Stem Cell Transplantation Patients: An Exploratory Descriptive Study

Background/Objectives: Patients receiving allogeneic hematopoietic stem cell transplantation (alloHCT) for acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are at high risk for severe disease and treatment-related complications and toxicities. Pharmacogenetic studies suggest that genetic variants can...

Lea P. A. Timmann, Pauline Lanting, L. Morsink et al. · 0 citations
Open access Jul 2026

Comparison of hiPSC-derived hepatic organoids and liver-on-a-chip systems reveal microenvironment-driven maturation

A cryopreservable and scalable workflow is developed to generate hiPSC-derived hepatic organoids that can be directly matured to either static HLOs or LoC systems, enabling matched comparison of both platforms and establishing a robust hiPSC-derived LoC platform.

Isabel Tamargo-Rubio, T. Krempel, Victoria Palasantzas et al. · 0 citations

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