BACKGROUND
Tuberculosis (TB) remains a global health issue. Treatment involves multiple anti-TB drugs, and pharmacokinetic variability may lead to toxicity or ineffective treatment. Therapeutic drug monitoring may help address these challenges. This study aimed to develop a rapid method to analyze anti-TB drugs in plas...
M. Bolhuis, E. M. Jongedijk, O. Akkerman et al.· Therapeutic Drug Monitoring· 0 citations
BACKGROUND AND OBJECTIVE
Tyrosine kinase inhibitors (TKIs) are targeted cancer therapies. However, TKIs are still limited due to their high inter-individual variability. This study evaluated target attainment using therapeutic drug monitoring (TDM) data from 12 TKIs, and investigated biochemical and patient-related cha...
Zaid N. Al Shirity, P. Mian, A. Dontje et al.· Clinical Pharmacokinetics· 0 citations
Background/Objectives: Patients receiving allogeneic hematopoietic stem cell transplantation (alloHCT) for acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are at high risk for severe disease and treatment-related complications and toxicities. Pharmacogenetic studies suggest that genetic variants can...
Lea P. A. Timmann, Pauline Lanting, L. Morsink et al.· Hemato· 0 citations
A cryopreservable and scalable workflow is developed to generate hiPSC-derived hepatic organoids that can be directly matured to either static HLOs or LoC systems, enabling matched comparison of both platforms and establishing a robust hiPSC-derived LoC platform.
Isabel Tamargo-Rubio, T. Krempel, Victoria Palasantzas et al.· bioRxiv· 0 citations
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