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Author

D. Thal

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3 papers indexed here

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Open access Oct 2026

Tau isoform mapping across tissues and biofluids reveals a signature distinguishing Alzheimer’s disease from amyotrophic lateral sclerosis

Blood phosphorylated tau 217 (p-tau217) accurately detects Alzheimer’s disease (AD) pathology but is also elevated in amyotrophic lateral sclerosis (ALS), likely reflecting peripheral (big) tau released from muscle. Assays selectively measuring brain-derived (BD-) tau and BD-p-tau217 are therefore needed. We analysed s...

S. Abu-Rumeileh, H. Großkopf, Arthur Guthknecht et al. · 0 citations
Review Open access Sep 2026

A new era of genome-wide association studies in the field of Alzheimer’s disease and overlapping co-pathologies: lessons learned from a neuropathology-centered approach

Alzheimer’s disease (AD) and overlapping pathologies represent a growing worldwide health concern. With the first disease-modifying treatments on the rise, it becomes increasingly important to move research in this area forward. Genetic research is excellent at discovering novel contributors to disease mechanisms, whic...

Celeste Laureyssen, D. Thal, K. Sleegers · 0 citations
Editorial Open access Aug 2026

Data-driven neuropathology modelling of neurodegenerative disorders: how to implement AI?

This scientific commentary refers to ‘Data-driven modelling of tau pathology reveals distinct progressive supranuclear palsy subtypes’ by Cullinane et al. (https://doi.org/10.1093/brain/awag131).

D. Thal, J. Schaeverbeke · 0 citations

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