Author

D. Standley

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Open access Oct 2026

Identification of small-molecule inhibitors of the immune system repressor Regnase-1

Regnase-1 is an essential RNase that suppresses immune cell activation by targeting the mRNA of pro-inflammatory cytokines such as interleukin 6 (IL-6). Although genetic inhibition of Regnase-1 activity in CD8+ T cells has been shown to enhance antitumor immunity, no molecular inhibitors of Regnase-1 have been report...

Arthur Millius, C. Yew, Yuko Misumi et al. · NAR Molecular Medicine · 0 citations

Open access Jul 2026

A germline shortcut in protein language model retrieval of adaptive immune receptors

It is shown that conventional random train-test splits inflate retrieval accuracy by 15–28 percentage points owing to clonal leakage, and clone-aware benchmarking as a practical standard of comparison is established, defining the strengths and limitations of frozen zero-shot PLM embeddings for immune receptor retrieval...

Suyue Wang, Ayan Sengupta, Song-Ling Li et al. · bioRxiv · 0 citations