Author

D. Simanshu

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Open access Oct 2026

Molecular mechanism of KRAS binding to BRAF and its regulation by the BRAF-specific region

SUMMARY MAPK pathway activation requires recruitment of RAF kinases by GTP-bound RAS through the RAS-binding domain (RBD) and cysteine-rich domain (CRD). BRAF uniquely contains an N-terminal BRAF-specific region (BSR), but the structural basis of KRAS engagement and BSR function remain unclear. Here, we report the stru...

D. Bonsor, Suzanne I. Sandin Lawrence, Timothy H. Tran et al. · Structure · 0 citations

Open access Sep 2026

Structural mechanisms underlying resistance to Switch-II pocket inhibitors in KRAS

Direct targeting of KRAS through the Switch-II pocket is an effective therapeutic strategy, but acquired resistance limits clinical benefit. We examine clinically observed resistance mutations (R68S, H95Q, Y96C, Y96D and Q99L) arising during KRAS G12C inhibitor therapy using biochemical, structural, computational and...

M. J. Whitley, M. Dyba, Mayukh Chakrabarti et al. · Nature Communications · 0 citations