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Sep 2026
Pancreatic ductal adenocarcinoma (PDAC) exhibits profound metabolic rewiring and strong resistance to DNA-damaging therapies, yet how metabolic pathways regulate genome maintenance remains poorly understood. The hexosamine biosynthetic pathway (HBP) integrates nutrient availability with protein glycosylation through pr...
Barbara Zerbato, Gabriele Taverna, Marina La Chimia et al.
· bioRxiv · 0 citations
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Open access
Sep 2026
This narrative review summarizes current evidence regarding the pharmacologic management of nociceptive, neuropathic, and nociplastic pain in children, integrating developmental pharmacology, efficacy data, safety considerations, and limitations of available evidence.
Gianmarco Marcianò, A. Leo, M. Caroleo et al.
· Children · 0 citations
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