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Open access Sep 2026

Overcoming Docetaxel Resistance in Prostate Cancer by Targeting Cell Cycle Progression with Narciclasine-Based Compounds

Development of resistance to taxane-based chemotherapy, specifically docetaxel (DTX), in advanced prostate cancer is frequent. Natural compounds, such as narciclasine, an alkaloid derived from plants, offer a potentially advantageous approach. Docetaxel-resistant prostate cancer cell lines (DU145RST and PC3RST) were es...

Ranyelison Silva Machado, Kaio S. Gomes, Augusto B. Farias et al. · 0 citations
Sep 2026

Tolerance, physical dependence, and Δ9-THC-like interoceptive effects of cannabinol in mice.

BACKGROUND AND PURPOSE Cannabinoids, including Δ9-tetrahydrocannabinol (THC) and synthetic CB1 agonists elicit acute psychotropic effects that undergo tolerance with repeated exposure. In contrast, the effects of prolonged cannabinol (CBN) use are unknown. This study examined (1) the effects of repeated CBN administrat...

S. Vanegas, J. Marusich, J. Maturano et al. · 0 citations

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