Author

D. Rubinow

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Open access Sep 2026

Epigenetic age acceleration is associated with brain connectivity changes and the risk of major depression after trauma

Background: Major depressive disorder (MDD) is associated with brain dysfunction and age-related diseases. Epigenetic clocks based on DNA methylation patterns estimate biological aging and aim to predict morbidity and mortality. Although MDD has been linked to epigenetic age acceleration (EAA) cross-sectionally, it is...

A. Navarro-Flores, Hazel Milla, S. Linnstaedt et al. · medRxiv · 0 citations

Open access Aug 2026

Stress-Related Methylation Risk Scores Predict Coronary Heart Disease

This study supports methylation risk scores as novel biomarkers of stress-related CHD and uncovers epigenetic regulation in monocytes as a potential underlying mechanism of stress-related CHD, highlighting biological pathways linking stress and disease and may promote personalized interventions in high-risk populations...

Sofia Benavides, Hazel Milla, Helena Palma-Gudiel et al. · medRxiv · 0 citations