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Review Open access Oct 2026

What are the potentials of the different sirtuin proteins as therapeutic targets?

INTRODUCTION Sirtuins (SIRT1-7) are NAD+-dependent lysine deacylase and mono-ADP ribosyl transferase enzymes that integrate metabolic status with epigenetic regulation, genome maintenance, mitochondrial homeostasis, and adaptive stress responses. Their dysregulation is implicated in cancer, neurodegeneration, cardiomet...

Emanuele Fabbrizi, G. Hailu, Andrea Mancini et al. · 0 citations

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