Optimized Lamotrigine-Loaded Polymeric Nanoparticles for Enhanced Drug Delivery: A Box-Behnken Design Approach with Integrated In Vivo Evaluation
Lamotrigine-loaded chitosan-sodium alginate polymeric nanoparticle system optimized by BoxBehnken Design demonstrated improved release control, enhanced pharmacokinetic parameters, and superior anticonvulsant activity in vivo, supporting their potential as a sustained-release system for epilepsy management.