Author

D. Piomelli

3 papers indexed here

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Sep 2026

Pharmacokinetic and pharmacodynamic profile of high-dose D9-tetrahydrocannabinol in male and female rats.

Cannabis products with elevated Δ9-tetrahydrocannabinol (THC) content are prevalent in parts of North America, yet their pharmacokinetic (PK) and pharmacodynamic (PD) properties remain incompletely characterized. We investigated the effects of a single administration of high-dose THC (10 and 30 mg/kg, intraperitoneal,...

O. Ajeigbe, Adren Tran, R. Klein et al. · Journal of Pharmacology and... · 0 citations

Sep 2026

Antinociceptive interaction of Δ9-tetrahydrocannabinol and cannabidiol in a humanized mouse model of sickle cell disease.

Sickle cell disease (SCD) is characterized by recurrent, debilitating pain. Opioid analgesics are routinely used in its management, but limited efficacy and pervasive side effects prompt many patients with SCD to seek alternatives, including cannabis. Prior work has shown that 2 major cannabis constituents, Δ9-tetrahyd...

Alex Mabou Tagne, O. Ajeigbe, Heidi C. Avalos et al. · Journal of Pharmacology and... · 0 citations

Open access Aug 2026

Iso‐ and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On‐Target Activity Through Scaffold Decoration and In Situ Warhead Generation

Monoacylglycerol lipase (MGL) is an intracellular serine hydrolase that regulates endocannabinoid signaling by hydrolyzing 2‐arachidonoylglycerol (2‐AG), thereby controlling cannabinoid receptor activity and related physiological processes. Targeting MGL through allosteric mechanisms is a promising strategy to modulate...

Edoardo Rocca, A. Bedini, L. Scalvini et al. · ChemMedChem · 0 citations