D. Pansare

Ultrasound-Assisted Synthesis of Isonicotinamide Derivatives Catalyzed by Biogenic ZrNPs and Their Biological Evaluation

In this study, we describe a one-pot, three-component synthesis method for creating N-(7-R)-2-oxa-6-azabicyclo[3.2.0]heptan-6-yl)isonicotinamide derivatives (4a–g). This method involves the condensation of isoniazid (1) with various aromatic aldehydes (2a–g), followed by a 2π+2π cycloaddition with 2,3-dihydrofuran (3),...