Open access
Jul 2026
Integrated single-cell and spatial transcriptomic analyses reveal an aging-associated fibroblast subtype linked to tumor progression in human skin
It is found that SFRP2-expressing fibroblasts accumulated in aged skin and were also enriched in tumor-associated stroma, suggesting that this pre-existing fibroblast state may become incorporated into and potentially support the tumor microenvironment during skin cancer development.
D. Pan, Haibin Wu
· Frontiers in Medicine · 0 citations