Cell-type definition is commonly achieved using marker genes. Because cell types are broadly conserved across evolution, marker genes are identifiable via interspecies comparisons. We generated single-cell RNA sequencing datasets of bone marrow niche and hematopoietic progenitor compartments from four mouse species. Us...
Lea C. Wölbert, Veronica F. Busa, Amy F. Danson et al.· Cell Genomics· 0 citations
Background & Aims Haematoxylin and eosin (H&E) staining remains the diagnostic gold standard for solid cancers, including hepatocellular carcinoma, and is increasingly complemented by genomic profiling for precision medicine. Inferring genomic alterations directly from H&E images could streamline testing, but heterogen...
John Connelly, Bárbara Hernando, Juliet Luft et al.· bioRxiv· 0 citations
The data support a model in which enhancer activation frequency depends on the cumulative function of multiple TFs and is modulated by p300 activity, and the contributions of transcription factor binding and chromatin context are dissected.