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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

D. Niopek

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#protein folding Open access Oct 2026

De novo design of light-controlled conformational protein switches

Light-responsive proteins offer the ability to control biology at an unmatched resolution. Yet, optogenetics is limited to a relatively small number of natural and engineered photoreceptors. The design of light-responsive proteins with native-like complexity is challenging as they must incorporate a light-responsive ch...

Alexander T. Hilditch, N. Goldbach, Chen-Xuan Liu et al. · 0 citations
Open access Jul 2026

Domain Insertion Improves the Precision of a CRISPR Adenine Base Editor

This work systematically map domain insertion sites within the high-activity TadA8e adenine base editor using structure-guided design and computational inference and finds that TadA8e accepts domain insertions at multiple surface sites, with overall activity and editing window width dependent on insert position rather...

Marik M. Müller, Nicholas T. Southern, D. Niopek · 0 citations

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