Author

D. Nachun

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Jul 2026

Somatic mutations reveal the ontogeny of microglia in human ageing.

An approach that uses the collection of accumulated somatic mutations that uniquely labels each clone of cells to track the infiltration of bone-marrow-derived cells into the human brain finds evidence of an influx of bone-marrow-derived cells into the brain in all examined individuals.

Julia A. Belk, Yao-Wen Zhang, Emily E. Reilly et al. · Nature · 2 citations

Open access Aug 2026

MetaDome 2027: a comprehensively updated resource for aggregating missense variant evidence across homologous human protein domains

The MetaDome 2027 update is presented, featuring a comprehensively updated dataset and GRCh38 support and showing how MetaDome helped reclassify a de novo missense VUS in RALA and identify 52,463 ClinVar missense VUS for which meta-domains supply otherwise unavailable pathogenic evidence.

Laurens Wiel, F. Ferraro, Jay Yu et al. · bioRxiv · 0 citations