Author

D. Mulder

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Open access Sep 2026

Disrupting peripheral serotonin synthesis drives sex-specific alterations in sociability and cognition, and reshapes the gut-immune-brain axis.

A role for peripheral 5-HT in behavioral regulation is supported and cross-system associations consistent with sex-specific modulation along the gut-immune-brain axis are revealed, while identifying TPH1-dependent signaling as a potential contributor to neuropsychiatric disorders' pathophysiology is identified.

Rogério C. R. Castro, N. Alenina, E. E. Natasha et al. · Brain, behavior, and immunit... · 0 citations

Open access Aug 2026

From gut to brain: data-driven evidence suggests causal contribution of gut-microbiota to major depressive disorder in humans

This study provides the first data-driven evidence for a potential causal role of gut microbiota in the pathophysiology of depression in humans, and employs state-of-the-art causal inference tools within Judea Pearl's framework.

L. Fehse, A. H. Ribeiro, N. Winter et al. · Gut microbes · 0 citations