Unconventional T cells recognize non-peptide antigens presented by molecules other than the major histocompatibility complex (MHC) proteins. Among unconventional T cells, natural killer T (NKT) cells, which recognize CD1d-lipid complexes, mucosal-associated invariant T (MAIT) cells, which recognize MR1-metabolite compl...
Alan Hsieh, Kattya Lopez, S. Leon et al.· bioRxiv· 0 citations
Mycobacterium tuberculosis (Mtb) is a major pathogen worldwide that infects and transmits only among humans, yet nearly all in vivo virulence research occurs in non-human hosts. To overcome this central challenge in tuberculosis research, we leveraged a dataset of more than 50,000 sequenced isolates to identify Mtb gen...
Gregory H. Babunovic, Sanne van der Niet, M. Gontijo et al.· bioRxiv· 0 citations
The data suggest that expression of PknF, as a modulator of multiple downstream effector proteins, restricts the virulence of Mtb in the lungs of mice through an NLRP3 inflammasome-independent mechanism, but potentially via suppressing production of the virulence lipid, PDIM.
Flor Torres-Juárez, Shivangi Rastogi, David C. Young et al.· Infection and Immunity· 0 citations
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