Author

D. Montefiori

3 papers indexed here

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Open access Sep 2026

Prophylactic treatment with broadly neutralizing antibody VRC01 selects for escape mutants after infection in Antibody-Mediated Prevention trials.

Broadly neutralizing antibodies (bnAbs) show promise in HIV prevention, yet viral escape remains a challenge. In the Antibody-Mediated Prevention (AMP) trials, the CD4 binding site (CD4bs) bnAb VRC01 blocked acquisition by VRC01-sensitive strains. However, its influence on viral evolution post acquisition is not fully...

Carolyn Williamson, Lyle Curry, Nonhlanhla N. Mkhize et al. · Nature Microbiology · 0 citations

Open access Aug 2026

Asymmetric Boost Responses to an HIV-1 Vaccine: Boost-site Controls Secondary B-cell Fates

This work shows that persistent germinal centers (GCs) support continued affinity maturation of founder clones and ipsilateral boosting preferentially engages these lineages in secondary GCs, and identifies disfavored mutational trajectories within the V3-glycan bnAb lineage, revealing intrinsic constraints on bnAb lin...

John S. Barber, K. Tonouchi, Chen-Hao Yeh et al. · bioRxiv · 0 citations

Open access Sep 2026

Preferential engagement of the anti-inflammatory ATP/adenosine axis by HIV vaccine candidate with V1-deleted envelope in male rhesus macaques

Ex vivo, ΔV1 gp120 reduced CCR5 expression on CD4+ T cells relative to WT gp120, consistent with the anti-inflammatory mucosal response by ΔV1-vaccine regimens in vivo, promotes an anti-inflammatory mucosal landscape less permissive to HIV seeding and dissemination following virus exposure.

Isabela Silva de Castro, Mohammad Arif Rahman, Massimiliano Bissa et al. · Cell Reports Medicine · 0 citations