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Author

D. Mendes-da-Cruz

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2 papers indexed here

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Open access Sep 2026

Aire Deficiency Disrupts Thymic Architecture but Preserves TCRVβ Repertoire Diversity While Altering Thymic Output.

The autoimmune regulator (Aire) gene is essential for the establishment of central tolerance by promoting the ectopic expression of tissue-restricted antigens in medullary thymic epithelial cells (mTECs). Although Aire deficiency impairs negative selection, its impact on thymic architecture, output, and early T cell de...

Adriana A. Matos, I. L. Araujo, M. Munuera et al. · 0 citations
Open access Sep 2026

The thymus gland is a target and maintainer of amyotrophic lateral sclerosis pathophysiology

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective loss of motor neurons in the brain and spinal cord with evidence of local neuroinflammation. Regulatory T cells (Treg) exert neuroprotective effects and correlate with disease progression, but central mechanisms gove...

Julia Pereira Lemos, Daniel Stockholm, B. Dinatale et al. · 0 citations

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