Open access
Aug 2026
Computational Structural Analysis of POLG Variants R627Q and W748S with Model-Variability Controls
Background Comparisons between independently predicted wild-type and missense-variant protein structures can generate mechanistic hypotheses, but small apparent differences may reflect model-selection variability rather than mutation-specific effects. Methods Human mitochondrial DNA polymerase gamma (POLG; UniProt P540...
Andrew Friedl, D. Manst
· bioRxiv · 0 citations