Review
Open access
Aug 2026
Endoplasmic Reticulum Stress-Driven Inflammatory Mediators in Metabolic Disorders: From Molecular Mechanisms to Targeted Therapies.
This review delineates how the canonical UPR sensors transduce metabolic stress into pro-inflammatory signaling cascades and discusses the organ-specific consequences of ERS in the liver, pancreas, adipose tissue, vascular endothelium, and hypothalamus, highlighting how this stress sustains a self-reinforcing cycle of tissue injury and metabolic dysfunction.
B. Wen, Xiaojin Wu, Kaiying Zhang et al.
· Pharmacological Research · 0 citations