Extracellular vesicles (EVs) are membrane-bound particles secreted by all cells and serve as critical mediators of intercellular communication in both physiological and pathological contexts. However, elucidating the precise functions of endogenous EVs remains challenged by a fundamental technical bottleneck: current i...
L. Borowski, A. Ramazanova, P. Alayrac et al.· bioRxiv· 0 citations
Medulloblastoma (MB) is the most common malignant pediatric brain tumor. The MYC‑amplified group 3 (G3) MB represents a high‑risk disease lacking effective therapies. A genetic screen identified the endoplasmic reticulum chaperone HSPA5 (BiP/GRP78) as a critical dependency in G3 MB. Its silencing induces apoptosis and...
Liliana Mirabal-Ortega, Sandra Majo, Lucie J. Taunay et al.· Nature Communications· 0 citations
ORF1p, a LINE-1-encoded protein, regulates chromatin accessibility, neuron-specific gene expression, and neurite morphology in post-mitotic neurons, revealing a physiological role for this retrotransposon protein in the brain.
Sandra Sinnassamy, Olivia Massiani Beaudoin, Bérangère Lombard et al.· Life Science Alliance· 0 citations
An untargeted proteomics profiling comparing pMBRT with conventional proton therapy in an orthotopic rat model of GB highlighted the dual capacity of pMBRT to sensitise tumours to radiation while preserving healthy brain tissue, supporting its translational potential for GB treatment.
L. Roncali, M. Riquelme-Pérez, R. G. Teles et al.· International Journal of Rad...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
