Open access
Sep 2026
Cluster-Based Phenotyping in an HFpEF Population Identifies a Biomarker-High, Atrial-Dysfunction Phenotype with Impaired Quality of Life, Reduced Exercise Capacity and Higher Healthcare Utilization
Background/Objectives: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. Atrial remodeling represents an important dimension of HFpEF beyond the presence of atrial fibrillation (AF). We aimed to identify clinically meaningful atrial phenotypes using unsupervised clustering. Methods: Ov...
S. Haack, Frank Edelmann, F. Spinka et al.
· Journal of Clinical Medicine · 0 citations